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DxMedical Cloud™
Technology for overwhelmingly high-speed detection from all over the world.
We use our unique algorithm to deliver the latest technology and product information from around the world in real time.
Explore the future of healthcare with carefully selected information.
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POINT 1.
Quickly Deliver Technical Information
We deliver what you seek quickly and in a short time from technical information from all over the world
POINT 2.
Briefly to the Point
A wealth of detailed features makes it easy to understand the main points
POINT 3.
Help with Growth Strategies
The report is also packed with analytical information from the perspective of growth and long-term strategies for business use
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In today's world, where the world is networked by advances in information technology and numerous technologies are evolving at an astonishing speed, it is extremely difficult to manually collect and manage the vast amount of information from all over the world.
DxMedical Cloud™ collects and analyzes professional information from around the world and uses proprietary algorithms to quickly and accurately deliver the information you seek and the best information for you.
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You can quickly search for information published in various languages around the world in Japanese. Get the information you need from the vast amount of information available worldwide without having to worry about language barriers.
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DxMedical Cloud's proprietary algorithms predict the best information based on your interests and preferences and deliver it to you daily. Stay one step ahead of the curve without the hassle of searching, maximizing your daily information gathering.
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In addition to word matching, the search by similar and related keywords delivers news that is often missed due to paraphrasing and shaky spelling.
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By providing titles and summaries of information from around the world in Japanese, it streamlines the process of “finding” the information you want from search results.
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For researchers and professionals, you can search and browse more specialized information, such as articles submitted to journals by universities and research institutes.
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Instantly save and manage information that you like or want to look at later because you don't have time, with the bookmark function. You can access the information you need without hassle, saving you a great deal of time and effort.
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Simple and intuitive operation allows you to quickly consolidate all information into a notebook and organize information efficiently. It can be used as a powerful tool for effective information sharing.
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A wide range of information sharing tools are available, including chat and note sharing functions. We support information sharing with your team in all situations, from casual information sharing to organizing information in teams.
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Provides task management functions specifically designed to make information gathering and sharing more efficient. In addition to regular task management functions, this useful tool supports information gathering and sharing, improving the productivity of the entire team.
DigitalMedical Open Innovation
BrainEnergy produce DigitalMedical open innovation from Tokyo, where you can experience the intersection of cool and passionate design and technology.
Transform Your Business With Cloud
Looking for the Future of Health Care
OUR TECHNOLOGY HELPS YOUR BUSINESS
Our technology will help your business
Technology
Extracting “Moisturizing Ingredients” from Untapped Resources: Creating New Value from Fermentation Byproducts
Hanamaruki, a manufacturer of miso and fermented products, is conducting research on extracting components involved in skin hydration from “shio-koji residue,” an underutilized byproduct generated during the manufacturing process. The company’s flagship product, liquid shio-koji, is a proprietary product made using a patented method, and the effective utilization of shio-koji residue—a byproduct of this process—has long been a challenge. While some of the residue has been used as animal feed in the past, much of it has remained unused. This research is being conducted as a joint project with Tokyo Denki University, which is engaged in developing technologies that utilize the benefits of microorganisms. The findings confirmed the presence of free sphingoid bases, and tests using human epidermal keratinocytes demonstrated that these compounds promote the expression of Caspase-14. This leads to the production of natural moisturizing factors through the degradation of filaggrin, and is expected to contribute to maintaining the skin’s barrier function. This component is also positioned as a “moisturizing switch,” and its novelty lies in the fact that it was extracted from an underutilized resource using a method that prioritizes safety. Tokyo Denki University is leading the extraction process, aiming to establish methods with low environmental impact. Progress is also being made in building a technological foundation with mass production in mind, such as enabling extraction using ethanol. Moving forward, the team plans to explore potential applications in high-value-added sectors such as cosmetic ingredients and dietary supplements. By focusing on the commonalities between microbial metabolism derived from fermentation and human physiological functions, the project aims to expand into the life sciences field through open innovation, while also creating new value through the upcycling of underutilized resources.
How Gut Microbes Shape Sleep: New Review Reveals Microbiome Clues to Insomnia and Apnea
News-Medical.net (November 5, 2025) reported on a review article published in Brain Medicine synthesizing evidence on microbiota-gut-brain interactions related to sleep disorders. With one in three adults reporting poor sleep, the origin may lie in the gut. In chronic insomnia, significant changes in gut microbiome composition occur, with decreases in beneficial genera such as Bifidobacterium and variations in the Firmicutes/Bacteroidetes ratio (F/B ratio). In obstructive sleep apnea (OSA), butyrate-producing bacteria decrease and pro-inflammatory bacteria increase. In REM sleep behavior disorder (RBD), decreases in butyrate-producing bacteria (such as Faecalibacterium and Butyricicoccus) may function as a precursor to Parkinson's disease. Key mechanisms include: (1) bile acid (BA) variation related to metabolic risk; (2) short-chain fatty acids (SCFAs) and polyamines regulating GABA and sleep-promoting factors; (3) tryptophan metabolism (gut serotonin→melatonin production); (4) GABA, serotonin, and dopamine signaling via vagus nerve. The review suggests new directions for microbiome-targeted sleep disorder treatments including diet, probiotics, and FMT (fecal microbiota transplantation).
Tiny Wireless Sensor in Tear Duct Monitors Inflammation and Blood Sugar Continuously ARPA-H-Funded UW-MIT-Northwestern Project
KOMO News (2026) reported on a microscopic wireless biosensor project led by Dr. Tueng Shen, an eye surgeon and bioengineer at UW Medicine, designed to fit inside a tear duct and continuously monitor biomarkers in tear fluid. Tears are produced constantly and—like blood, saliva, and sweat—carry proteins, molecules, and other substances indicating what is happening inside the body. The sensor, intended for the tear duct (puncta), a space roughly 1–2 millimeters across, would wirelessly transmit continuous readings on two initial targets: inflammation and blood-sugar levels, aiming to provide a needle-free monitoring method for conditions such as diabetes. The design is modeled on tear-duct plugs already used to treat dry eye—no surgery required, minimal anesthesia, with a target lifespan of approximately six months. The device would be manufactured using 3D-printing techniques developed by Northwestern University. Funding comes from ARPA-H (Advanced Research Projects Agency for Health), under the OCULAB initiative (ARPA-H-SOL-25-115). The project is a collaboration among MIT (lead institution), the University of Washington, and Northwestern University. Dr. Shen noted: 'If we can do this in a space as small as a tear duct, we can use the same technology in a much bigger space like the skin or the intestine—a broad health-monitoring platform.'
Targeted Antimicrobial Peptide Toothpaste Kills Gum Disease Bacteria While Protecting Healthy Oral Flora New Approach Overcomes Broad-Spectrum Bactericidal Effects of Conventional Toothpaste
SciTechDaily (2026) reported on the development of a toothpaste that selectively kills periodontal disease-causing bacteria while leaving the healthy oral microbiome (resident flora) unharmed. Conventional toothpastes and antimicrobial mouthwashes often use broad-spectrum bactericidal agents such as chlorhexidine, which eliminate not only periodontal pathogens but also beneficial resident bacteria—a longstanding dilemma in oral care. The new approach utilizes antimicrobial peptides that selectively bind to and kill major periodontal pathogens (anaerobic oral bacteria such as Porphyromonas gingivalis). Because the peptides target specific components of the bacterial membrane found in these pathogens, they are designed not to act against structurally different beneficial resident bacteria. Periodontal disease affects approximately half of Japanese adults and is a risk factor for cardiovascular disease, diabetes, and dementia. The approach offers potential as a daily care supplement to conventional treatments (scaling, root planing, antibiotics) and is attracting attention from the perspective of protecting the oral microbiome.
1 Hotel Tokyo Makes Waves: Luxury Meets Nature in Groundbreaking Eco-Hotel Revolutionising Japan's Travel Scene
SH Hotels & Resorts has marked its first entry into the Japanese market with the official opening of 1 Hotel Tokyo, located within the prestigious Akasaka Trust Tower in Tokyo. The property applies a cutting-edge biophilic design philosophy to bridge the gap between high-tech urban living and the natural environment, setting a new benchmark for sustainable luxury hotels in Asia. The hotel features 211 guest rooms including 24 suites and 3 penthouses, where Oya stone—a porous volcanic rock native to Japan—is paired with installations of preserved moss to evoke the serenity of a traditional Japanese garden. Organic textures and reclaimed materials are used throughout to minimize the carbon footprint. The architectural narrative incorporates the rhythm of Japan's four seasons into the structural framework, balancing functionality with a premium guest experience. As responsible tourism continues to gain momentum, industry analysts regard 1 Hotel Tokyo as a potential blueprint for the broader Japanese hospitality sector, demonstrating that luxury and sustainability are not mutually exclusive. The brand's ability to successfully export its eco-conscious ethos to one of the world's most discerning markets has reinforced its standing as a global leader in the movement toward a more harmonious relationship between the built environment and nature.
Quality Management Software Firm Selects 25 Medical Device Startups to Watch in 2026 Across Neurotech, Surgical Robotics, and At-Home Diagnostics
Qualio (December 9, 2025, by Lola Furlong) published a curated list of 25 medical device startups to watch in 2026. With the medtech industry projected to generate over $600 billion in revenue in 2026, the article notes—citing McKinsey research—that leading medtech companies provide consistently superior experiences to all users and stakeholders while reimagining processes to reduce costs and accelerate decisions. The 25 selected companies span a broad range of categories: CergenX (neonatal neurological monitoring), ComeBack Mobility (spinal cord injury rehabilitation), ThinkBio.AI (AI medical data), Boston Micro Fabrication (micro-scale manufacturing), Polycarbin (recycling medical waste), ABLE Human Motion (exoskeletons), Garwood Medical Devices (surgical staplers), Parasym Health (vagus nerve stimulation), HemoSonics (hemostasis monitoring), CMR Surgical (surgical robotics), EvoEndo (endoscopy), Francis Medical (prostate cancer treatment), Healthy.io (smartphone-based at-home diagnostics), InVivo Bionics (spinal cord injury wearables), Axion BioSystems (cellular electrophysiology), Béa Fertility (at-home intrauterine insemination), Flow Neuroscience (tDCS for depression), Synchron (brain-implanted BCI), Shockwave Medical (intravascular lithotripsy), SimBioSys (AI breast cancer imaging), Ibex (AI cancer pathology), BiVacor (total artificial heart), Hemotune (extracorporeal blood purification), xCures (AI treatment matching for cancer patients), and Enable Injections (large-volume subcutaneous drug delivery).
One-Step 3D-Printed ZrO₂/Cu Metamaterial Electrode Achieves ~6× Higher Sensitivity for Enzyme-Free Glucose Sensing in Alkaline Electrolyte
AZoM (March 12, 2026, by Akshatha Chandrashekar) reported on a study published in CMat (DOI: 10.1002/cmt2.70030) presenting a one-step 3D-printing method to fabricate a binder-free ZrO₂/Cu metamaterial electrode for enzyme-free glucose sensing. Conventional glucose sensors rely on enzymes such as glucose oxidase, whose activity degrades under changing temperature, pH, or humidity; nonenzymatic sensors address this by driving glucose oxidation directly at the electrode surface. The research team used digital light processing (DLP) to print a polyethylene glycol diacrylate (PEGDA) hydrogel lattice in a six-membered tricapped trigonal prism geometry, then soaked it in copper chloride and zirconium chloride precursor solutions to allow metal ion diffusion throughout the network. Controlled calcination in argon converted the hydrogel into a conductive carbon scaffold while forming Cu, copper oxide, and nanoscale oxygen-deficient ZrO₂. Microscopy confirmed that ~10 nm ZrO₂ nanoparticles formed on the surface of larger Cu particles, creating a ZrO₂/Cu interface that altered the electronic state of copper, promoted catalytically active Cu⁺ species, improved glucose adsorption via Lewis-acid Zr⁴⁺ sites, and lowered the barrier for glucose oxidation and charge transfer. The optimized electrode achieved a glucose sensitivity of approximately 1,093 μA mM⁻¹ cm⁻² over a range of 0.05–1.50 mM—roughly six times higher than the Cu-only control (~183 μA mM⁻¹ cm⁻²)—and an electrochemically active surface area approximately 13 times greater than the copper control. The electrode retained 97.39% of its current after ~170 minutes of continuous operation and showed stable repeat measurements over seven days. Selectivity tests against NaCl, KCl, sucrose, citric acid, and urea showed low interference signals. The work remains a laboratory demonstration in alkaline electrolyte, with further validation in real-sample environments as the next step.
Faster, More Stable Enzymes Designed Using Artificial Intelligence
Researchers at Graz University of Technology and the University of Graz have developed Riff-Diff, a new AI-driven method for designing customized enzymes that are significantly faster and more stable. This technology precisely builds protein structures around active centers, creating highly efficient biocatalysts for industrial, medical, and environmental applications. Leveraging machine learning, Riff-Diff accelerates enzyme development, achieving high thermal stability (over 90 degrees Celsius) and making enzyme design more accessible to the biotechnology community.
Gas Chromatography-Based Biosensor for Detecting Fruit Ripeness Monitoring the Ripening Process of Stored Fruit
Strella Biotech develops and manufactures gas chromatography-based biosensors that detect fruit ripeness. By installing sensors in controlled atmosphere (CA) storage facilities and monitoring the ripening process of stored fruit, the company helps packers and distributors identify the location of the ripest fruit. This contributes to improved shipping decisions, enhanced inventory management accuracy, and reduced food waste.
Test strip with enhanced technology could make way for more accessible diagnosis
A research team led by La Trobe University has developed a single-use test strip that could ultimately change how diseases like cancer are diagnosed. The research used enzymes to boost an electrical signal to detect disease-indicative molecules, also known as microRNAs.
AI Glasses: Ushering in the Next Generation of Advanced Wearable Technology
AI glasses are rapidly advancing, offering features like teleprompting, object recognition, and real-time translation, but face significant battery life challenges due to high-performance processors and increased leakage current. NXP Semiconductors addresses this with its i.MX RT low-power product family, specifically the i.MX RT700. This chip supports a dual-architecture approach, enabling extended battery life through an application processor and coprocessor, or a lighter, smaller MCU-only design. The RT700 optimizes power consumption in various scenarios, including voice control with sensor mode operation under 2mW, and high-performance display modes, leveraging technologies like MIPI ULPS for efficient multimedia processing.
PHC Launches Non-Fluorocarbon Large-Capacity Freezer-Equipped Pharmaceutical Refrigerator “MPR-N650FH/MPR-N650FSH” in Japan This December ~ Contributing to Improved Pharmaceutical Freezing/Refrigeration Storage Quality and Reduced Environmental Impact ~
PHC Holdings Corporation (Headquarters: Chiyoda-ku, Tokyo) subsidiary PHC Corporation Biomedica Division (Headquarters: Chiyoda-ku, Tokyo; President and CEO: Nobuaki Nakamura; hereinafter “PHCbi”) will begin sales of the “MPR-N650FH/MPR-N650FSH” (*1) pharmaceutical refrigerators with non-fluorocarbon-based -30°C large-capacity freezers in December 2025. These refrigerators offer enhanced cooling performance and energy efficiency for pharmaceutical companies, research facilities, and medical institutions.
A Single Molecule May Explain How Blood Flow in The Brain Triggers Dementia
Reduced blood flow to the brain is thought to be a key factor in many forms of dementia, including Alzheimer's, and scientists have just identified a new mechanism regulating this flow, which may also help explain how it goes wrong. A fat molecule helps maintain the system's balance, researchers at the University of Vermont discovered, and in mouse models of Alzheimer's disease, disruption of this balance led to problems. Fixing the imbalance restored more normal blood flow, offering a hopeful new target for understanding and treating dementia-related brain changes. "This discovery is a huge step forward in our efforts to prevent dementia and neurovascular diseases," says pharmacologist Osama Harraz.
More
DxMedical Cloud™
Technology for overwhelmingly high-speed detection from all over the world.
We use our unique algorithm to deliver the latest technology and product information from around the world in real time.
Explore the future of healthcare with carefully selected information.
Start a free trial chevron_right
How We Help You To Empower Your Business
POINT 1.
Quickly Deliver Technical Information
We deliver what you seek quickly and in a short time from technical information from all over the world
POINT 2.
Briefly to the Point
A wealth of detailed features makes it easy to understand the main points
POINT 3.
Help with Growth Strategies
The report is also packed with analytical information from the perspective of growth and long-term strategies for business use
DigitalMedical Open Innovation
デジタル・メディカル・オープンイノベーション
BrainEnergy produce DigitalMedical open innovation from Tokyo, where you can experience the intersection of cool and passionate design and technology.
Transform Your Business With Cloud
Looking for the Future
of Health Care
OUR TECHNOLOGY HELPS
YOUR BUSINESS
Our technology will help your business
Technology
Extracting “Moisturizing Ingredients” from Untapped Resources: Creating New Value from Fermentation Byproducts
Hanamaruki, a manufacturer of miso and fermented products, is conducting research on extracting components involved in skin hydration from “shio-koji residue,” an underutilized byproduct generated during the manufacturing process. The company’s flagship product, liquid shio-koji, is a proprietary product made using a patented method, and the effective utilization of shio-koji residue—a byproduct of this process—has long been a challenge. While some of the residue has been used as animal feed in the past, much of it has remained unused. This research is being conducted as a joint project with Tokyo Denki University, which is engaged in developing technologies that utilize the benefits of microorganisms. The findings confirmed the presence of free sphingoid bases, and tests using human epidermal keratinocytes demonstrated that these compounds promote the expression of Caspase-14. This leads to the production of natural moisturizing factors through the degradation of filaggrin, and is expected to contribute to maintaining the skin’s barrier function. This component is also positioned as a “moisturizing switch,” and its novelty lies in the fact that it was extracted from an underutilized resource using a method that prioritizes safety. Tokyo Denki University is leading the extraction process, aiming to establish methods with low environmental impact. Progress is also being made in building a technological foundation with mass production in mind, such as enabling extraction using ethanol. Moving forward, the team plans to explore potential applications in high-value-added sectors such as cosmetic ingredients and dietary supplements. By focusing on the commonalities between microbial metabolism derived from fermentation and human physiological functions, the project aims to expand into the life sciences field through open innovation, while also creating new value through the upcycling of underutilized resources.
DxMedical Cloud™︎
How Gut Microbes Shape Sleep: New Review Reveals Microbiome Clues to Insomnia and Apnea
News-Medical.net (November 5, 2025) reported on a review article published in Brain Medicine synthesizing evidence on microbiota-gut-brain interactions related to sleep disorders. With one in three adults reporting poor sleep, the origin may lie in the gut. In chronic insomnia, significant changes in gut microbiome composition occur, with decreases in beneficial genera such as Bifidobacterium and variations in the Firmicutes/Bacteroidetes ratio (F/B ratio). In obstructive sleep apnea (OSA), butyrate-producing bacteria decrease and pro-inflammatory bacteria increase. In REM sleep behavior disorder (RBD), decreases in butyrate-producing bacteria (such as Faecalibacterium and Butyricicoccus) may function as a precursor to Parkinson's disease. Key mechanisms include: (1) bile acid (BA) variation related to metabolic risk; (2) short-chain fatty acids (SCFAs) and polyamines regulating GABA and sleep-promoting factors; (3) tryptophan metabolism (gut serotonin→melatonin production); (4) GABA, serotonin, and dopamine signaling via vagus nerve. The review suggests new directions for microbiome-targeted sleep disorder treatments including diet, probiotics, and FMT (fecal microbiota transplantation).
News-Medical.net
Tiny Wireless Sensor in Tear Duct Monitors Inflammation and Blood Sugar Continuously ARPA-H-Funded UW-MIT-Northwestern Project
KOMO News (2026) reported on a microscopic wireless biosensor project led by Dr. Tueng Shen, an eye surgeon and bioengineer at UW Medicine, designed to fit inside a tear duct and continuously monitor biomarkers in tear fluid. Tears are produced constantly and—like blood, saliva, and sweat—carry proteins, molecules, and other substances indicating what is happening inside the body. The sensor, intended for the tear duct (puncta), a space roughly 1–2 millimeters across, would wirelessly transmit continuous readings on two initial targets: inflammation and blood-sugar levels, aiming to provide a needle-free monitoring method for conditions such as diabetes. The design is modeled on tear-duct plugs already used to treat dry eye—no surgery required, minimal anesthesia, with a target lifespan of approximately six months. The device would be manufactured using 3D-printing techniques developed by Northwestern University. Funding comes from ARPA-H (Advanced Research Projects Agency for Health), under the OCULAB initiative (ARPA-H-SOL-25-115). The project is a collaboration among MIT (lead institution), the University of Washington, and Northwestern University. Dr. Shen noted: 'If we can do this in a space as small as a tear duct, we can use the same technology in a much bigger space like the skin or the intestine—a broad health-monitoring platform.'
KOMO News
Targeted Antimicrobial Peptide Toothpaste Kills Gum Disease Bacteria While Protecting Healthy Oral Flora New Approach Overcomes Broad-Spectrum Bactericidal Effects of Conventional Toothpaste
SciTechDaily (2026) reported on the development of a toothpaste that selectively kills periodontal disease-causing bacteria while leaving the healthy oral microbiome (resident flora) unharmed. Conventional toothpastes and antimicrobial mouthwashes often use broad-spectrum bactericidal agents such as chlorhexidine, which eliminate not only periodontal pathogens but also beneficial resident bacteria—a longstanding dilemma in oral care. The new approach utilizes antimicrobial peptides that selectively bind to and kill major periodontal pathogens (anaerobic oral bacteria such as Porphyromonas gingivalis). Because the peptides target specific components of the bacterial membrane found in these pathogens, they are designed not to act against structurally different beneficial resident bacteria. Periodontal disease affects approximately half of Japanese adults and is a risk factor for cardiovascular disease, diabetes, and dementia. The approach offers potential as a daily care supplement to conventional treatments (scaling, root planing, antibiotics) and is attracting attention from the perspective of protecting the oral microbiome.
SciTechDaily
1 Hotel Tokyo Makes Waves: Luxury Meets Nature in Groundbreaking Eco-Hotel Revolutionising Japan's Travel Scene
SH Hotels & Resorts has marked its first entry into the Japanese market with the official opening of 1 Hotel Tokyo, located within the prestigious Akasaka Trust Tower in Tokyo. The property applies a cutting-edge biophilic design philosophy to bridge the gap between high-tech urban living and the natural environment, setting a new benchmark for sustainable luxury hotels in Asia. The hotel features 211 guest rooms including 24 suites and 3 penthouses, where Oya stone—a porous volcanic rock native to Japan—is paired with installations of preserved moss to evoke the serenity of a traditional Japanese garden. Organic textures and reclaimed materials are used throughout to minimize the carbon footprint. The architectural narrative incorporates the rhythm of Japan's four seasons into the structural framework, balancing functionality with a premium guest experience. As responsible tourism continues to gain momentum, industry analysts regard 1 Hotel Tokyo as a potential blueprint for the broader Japanese hospitality sector, demonstrating that luxury and sustainability are not mutually exclusive. The brand's ability to successfully export its eco-conscious ethos to one of the world's most discerning markets has reinforced its standing as a global leader in the movement toward a more harmonious relationship between the built environment and nature.
Travel And Tour World
Quality Management Software Firm Selects 25 Medical Device Startups to Watch in 2026 Across Neurotech, Surgical Robotics, and At-Home Diagnostics
Qualio (December 9, 2025, by Lola Furlong) published a curated list of 25 medical device startups to watch in 2026. With the medtech industry projected to generate over $600 billion in revenue in 2026, the article notes—citing McKinsey research—that leading medtech companies provide consistently superior experiences to all users and stakeholders while reimagining processes to reduce costs and accelerate decisions. The 25 selected companies span a broad range of categories: CergenX (neonatal neurological monitoring), ComeBack Mobility (spinal cord injury rehabilitation), ThinkBio.AI (AI medical data), Boston Micro Fabrication (micro-scale manufacturing), Polycarbin (recycling medical waste), ABLE Human Motion (exoskeletons), Garwood Medical Devices (surgical staplers), Parasym Health (vagus nerve stimulation), HemoSonics (hemostasis monitoring), CMR Surgical (surgical robotics), EvoEndo (endoscopy), Francis Medical (prostate cancer treatment), Healthy.io (smartphone-based at-home diagnostics), InVivo Bionics (spinal cord injury wearables), Axion BioSystems (cellular electrophysiology), Béa Fertility (at-home intrauterine insemination), Flow Neuroscience (tDCS for depression), Synchron (brain-implanted BCI), Shockwave Medical (intravascular lithotripsy), SimBioSys (AI breast cancer imaging), Ibex (AI cancer pathology), BiVacor (total artificial heart), Hemotune (extracorporeal blood purification), xCures (AI treatment matching for cancer patients), and Enable Injections (large-volume subcutaneous drug delivery).
Qualio
One-Step 3D-Printed ZrO₂/Cu Metamaterial Electrode Achieves ~6× Higher Sensitivity for Enzyme-Free Glucose Sensing in Alkaline Electrolyte
AZoM (March 12, 2026, by Akshatha Chandrashekar) reported on a study published in CMat (DOI: 10.1002/cmt2.70030) presenting a one-step 3D-printing method to fabricate a binder-free ZrO₂/Cu metamaterial electrode for enzyme-free glucose sensing. Conventional glucose sensors rely on enzymes such as glucose oxidase, whose activity degrades under changing temperature, pH, or humidity; nonenzymatic sensors address this by driving glucose oxidation directly at the electrode surface. The research team used digital light processing (DLP) to print a polyethylene glycol diacrylate (PEGDA) hydrogel lattice in a six-membered tricapped trigonal prism geometry, then soaked it in copper chloride and zirconium chloride precursor solutions to allow metal ion diffusion throughout the network. Controlled calcination in argon converted the hydrogel into a conductive carbon scaffold while forming Cu, copper oxide, and nanoscale oxygen-deficient ZrO₂. Microscopy confirmed that ~10 nm ZrO₂ nanoparticles formed on the surface of larger Cu particles, creating a ZrO₂/Cu interface that altered the electronic state of copper, promoted catalytically active Cu⁺ species, improved glucose adsorption via Lewis-acid Zr⁴⁺ sites, and lowered the barrier for glucose oxidation and charge transfer. The optimized electrode achieved a glucose sensitivity of approximately 1,093 μA mM⁻¹ cm⁻² over a range of 0.05–1.50 mM—roughly six times higher than the Cu-only control (~183 μA mM⁻¹ cm⁻²)—and an electrochemically active surface area approximately 13 times greater than the copper control. The electrode retained 97.39% of its current after ~170 minutes of continuous operation and showed stable repeat measurements over seven days. Selectivity tests against NaCl, KCl, sucrose, citric acid, and urea showed low interference signals. The work remains a laboratory demonstration in alkaline electrolyte, with further validation in real-sample environments as the next step.
AZoM
Faster, More Stable Enzymes Designed Using Artificial Intelligence
Researchers at Graz University of Technology and the University of Graz have developed Riff-Diff, a new AI-driven method for designing customized enzymes that are significantly faster and more stable. This technology precisely builds protein structures around active centers, creating highly efficient biocatalysts for industrial, medical, and environmental applications. Leveraging machine learning, Riff-Diff accelerates enzyme development, achieving high thermal stability (over 90 degrees Celsius) and making enzyme design more accessible to the biotechnology community.
Technology Networks
Gas Chromatography-Based Biosensor for Detecting Fruit Ripeness Monitoring the Ripening Process of Stored Fruit
Strella Biotech develops and manufactures gas chromatography-based biosensors that detect fruit ripeness. By installing sensors in controlled atmosphere (CA) storage facilities and monitoring the ripening process of stored fruit, the company helps packers and distributors identify the location of the ripest fruit. This contributes to improved shipping decisions, enhanced inventory management accuracy, and reduced food waste.
Strella Biotechnology
Test strip with enhanced technology could make way for more accessible diagnosis
A research team led by La Trobe University has developed a single-use test strip that could ultimately change how diseases like cancer are diagnosed. The research used enzymes to boost an electrical signal to detect disease-indicative molecules, also known as microRNAs.
Medical Xpress
AI Glasses: Ushering in the Next Generation of Advanced Wearable Technology
AI glasses are rapidly advancing, offering features like teleprompting, object recognition, and real-time translation, but face significant battery life challenges due to high-performance processors and increased leakage current. NXP Semiconductors addresses this with its i.MX RT low-power product family, specifically the i.MX RT700. This chip supports a dual-architecture approach, enabling extended battery life through an application processor and coprocessor, or a lighter, smaller MCU-only design. The RT700 optimizes power consumption in various scenarios, including voice control with sensor mode operation under 2mW, and high-performance display modes, leveraging technologies like MIPI ULPS for efficient multimedia processing.
ELE Times
PHC Launches Non-Fluorocarbon Large-Capacity Freezer-Equipped Pharmaceutical Refrigerator “MPR-N650FH/MPR-N650FSH” in Japan This December ~ Contributing to Improved Pharmaceutical Freezing/Refrigeration Storage Quality and Reduced Environmental Impact ~
PHC Holdings Corporation (Headquarters: Chiyoda-ku, Tokyo) subsidiary PHC Corporation Biomedica Division (Headquarters: Chiyoda-ku, Tokyo; President and CEO: Nobuaki Nakamura; hereinafter “PHCbi”) will begin sales of the “MPR-N650FH/MPR-N650FSH” (*1) pharmaceutical refrigerators with non-fluorocarbon-based -30°C large-capacity freezers in December 2025. These refrigerators offer enhanced cooling performance and energy efficiency for pharmaceutical companies, research facilities, and medical institutions.
PHCホールディングス
A Single Molecule May Explain How Blood Flow in The Brain Triggers Dementia
Reduced blood flow to the brain is thought to be a key factor in many forms of dementia, including Alzheimer's, and scientists have just identified a new mechanism regulating this flow, which may also help explain how it goes wrong. A fat molecule helps maintain the system's balance, researchers at the University of Vermont discovered, and in mouse models of Alzheimer's disease, disruption of this balance led to problems. Fixing the imbalance restored more normal blood flow, offering a hopeful new target for understanding and treating dementia-related brain changes. "This discovery is a huge step forward in our efforts to prevent dementia and neurovascular diseases," says pharmacologist Osama Harraz.
ScienceAlert