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12-Week Supplementation with Silkworm Cordyceps Militaris Significantly Improves Male Menopausal Symptoms in Men 40+ in Randomized Double-Blind Placebo-Controlled Trial: Significant Improvements in Total AMS Score, Psychological and Physical Subscales (Published in Japanese Anti-Aging Medicine Journal)
Dai-ichi Kogyo Seiyaku Co., Ltd. (Kyoto) announced on March 16, 2026, that a clinical trial has confirmed supplementation with the food ingredient silkworm Cordyceps militaris (Silkworm Cordyceps) improves male menopausal symptoms in men aged 40 and over. The results were published in the February 2026 issue of 'Anti-Aging Medicine,' the journal of the Japan Society of Anti-Aging Medicine. Male menopausal symptoms—including depression, sleep disorders, sexual dysfunction, irritability, and hot flashes—significantly affect men's quality of life and have been associated with metabolic syndrome, cardiovascular disease, and dementia risk. The company had previously demonstrated that Silkworm Cordyceps improves sleep quality and increases testosterone levels in obese men. The current study was a randomized, placebo-controlled, double-blind parallel-group comparative trial in 68 men aged 40 and over (65 analyzed), comparing 12 weeks of Silkworm Cordyceps versus placebo supplementation. Outcome measures were the Aging Male Symptoms (AMS) questionnaire total score and three subscales: psychological, somatic, and sexual function factors. The results showed statistically significant improvement in the total AMS score as well as the psychological and somatic subscales. The company states it will continue to advance research on Silkworm Cordyceps to address the challenges of stress-laden and rapidly aging societies.
Unilever Adjusts Marketing to Respond Faster to Consumer Trends
Marketing Tech News (2026) reported on Unilever's 'Desire at Scale' strategy advocated by Chief Growth and Marketing Officer Esi Eggleston Bracey. Strategy overview: Links brands more closely and quickly to culture, community, and commerce to drive sales. Positioned in the 2025 annual report as part of building 'a faster, simpler and technology-enabled organisation Fit for the AI Age.' Impact on product development: Using Sunsilk as an example, the brand was reshaped around Gen Z beauty trends through social-first marketing and new product ideas (Wondermist hair perfume mist: fragrance technology tied to emotion and confidence). Kantar research reports that 8 in 10 consumers seek holistic beauty routines including self-care. Significance: In an era where social media shapes awareness, product discovery, and quickly follows with buying intent, strengthening the link between social trends and product launches is essential. Speed vs. credibility balance challenge: Emotional language alone is insufficient; combination with scientific evidence and ingredient stories is needed. The ability to discern 'which signals matter and which do not' is becoming a competitive advantage for major brands.
Higher Skin Carotenoid Levels Linked to Lower Periodontal Disease Prevalence—VegiCheck and Health Big Data Analysis Confirms Significant Association with Lutein and Lycopene
PR TIMES (March 23, 2026) reported on research published in Nutrition Journal (DOI: 10.1186/s12937-026-01285-y) from a collaboration between Kagome and Hirosaki University's 'Vegetable Life Science Department.' The study utilized health big data from Hirosaki University's Iwaki Health Promotion Project, analyzing the association between skin carotenoids and periodontal disease in 456 adults with normal occlusion (mean age 48.0 years; 50.9% with periodontal disease). Skin carotenoid levels were measured using the VegiCheck® device (approximately 30 seconds for skin carotenoid/estimated vegetable intake measurement) and blood carotenoid concentrations were also assessed. After adjusting for age, sex, smoking, alcohol consumption, dietary habits, and dental hygiene, logistic regression analysis was performed. Key results: (1) The highest skin carotenoid quintile showed significantly lower periodontal disease prevalence compared to the lowest quintile; (2) Higher blood lutein and lycopene concentrations were significantly associated with lower periodontal disease prevalence; (3) Bayesian network analysis suggested carotenoids may prevent periodontal disease by suppressing oral inflammation and disruption of oral microbiota. As approximately half of Japanese adults have periodontal disease—also a risk factor for cardiovascular disease and dementia—this finding points to a non-invasive screening and prevention approach via vegetable intake and carotenoids.
Morinaga Milk Group Begins Using Dried Black Tea Lees from Beverage Production as Cattle Feed
Morinaga Milk Group has launched an in-house resource circulation initiative in which black tea lees—a byproduct of its paper-pack black tea beverage production—are dried, processed, and repurposed as cattle feed. The dried tea lees, previously treated as industrial waste at Yokohama Morinaga Milk's facility in Ayase, Kanagawa, are now transported to the Nasudairoku Farm operated by Morinaga Dairy Sales in Tochigi Prefecture, where they are fed to the farm's cattle. The initiative draws on findings from a joint study conducted since 2021 with Shinshu University, Northern Farm Co., Ltd., and the Morinaga Dairy Farming Promotion Foundation, which confirmed that feeding black tea lees to dairy cows reduced rumen methane production by approximately 9% under certain conditions—results that were presented at the International Dairy Federation (IDF) World Dairy Summit in Chicago in October 2023. While the current initiative is not specifically designed to verify methane suppression, the company intends to continue research and validation with the aim of contributing to future GHG reductions. The effort aligns with Morinaga Milk's Sustainability Mid-to-Long-Term Plan 2030, which targets a reduction of Scope 3 CO2 emissions by at least 10% compared to fiscal 2020 levels.
Printable enzyme ink powers next-generation wearable biosensors
A research team led by Associate Professor Isao Shitanda at Tokyo University of Science (TUS) has developed water-based 'enzyme inks' that simplify the fabrication of enzymatic biofuel cells (EBFCs) into a single screen-printing step, overcoming longstanding barriers to mass-producing self-powered wearable biosensors. Conventional EBFC manufacturing requires multiple labor-intensive steps—printing carbon electrodes, drop-casting enzyme and mediator solutions, and drying—resulting in high variability and impractical scalability. The new ink formulation combines magnesium oxide-templated mesoporous carbon, chemical mediators, a novel water-based polymer binder (POLYSOL), and carboxymethyl cellulose as a thickener, with specific enzymes such as lactate oxidase or glucose dehydrogenase added depending on the target analyte. Crucially, all components are dispersed in water to preserve enzyme activity. Printed electrodes significantly outperformed drop-cast counterparts, maintaining stable performance over extended periods. A complete lactate/oxygen biofuel cell achieved a maximum power output of 165 μW/cm², surpassing the 96 μW/cm² of prior systems. The team has already demonstrated self-powered wireless lactate monitoring via Bluetooth Low Energy, and validated roll-to-roll printing over 400 m of substrate—pointing toward production costs as low as approximately 10 yen per device. Practical implementation is targeted for around 2030, with potential applications in sports performance monitoring, elderly care, and heatstroke prevention.
Joint Study by Two Universities and Food Company Establishes Technology to Control Oleogel Crystal Shape and Length, Improving Mechanical Strength Up to ~40-Fold for Plant-Based Food Applications
Miyoshi Oil & Fat Co., Ltd. (February 20, 2026) announced that a joint research team with Hiroshima University and Hokkaido University established a technology for controlling the morphology of lipid whisker crystals in oleogels, published in Food Research International (December 4, 2025; DOI: 10.1016/j.foodres.2025.117999). Oleogels—solid structures formed by gelling liquid oil with a small amount of structuring agent—are promising materials for replicating the 'juiciness' of animal fat in plant-based foods (PBF) such as meat alternatives. Using high-purity PSP (1,3-dipalmitoyl-2-stearoylglycerol), the team demonstrated two key mechanisms for controlling physical properties: (1) 'Length control': raising tempering temperature above 30°C increases whisker crystal length and significantly improves storage modulus (hardness); at 40°C, crystallite size reaches approximately 240 nm and electron diffraction patterns characteristic of long-period structures are observed. (2) 'Shape control': incorporating 37.2% impurities (FHHPMF) transforms crystals from straight to wavy (serpentine) form, increasing the critical strain (mechanical strength index) from 0.54% to 21.2%—approximately a 40-fold improvement. Beyond PBF applications, the technology has broad potential for texture design in processed foods, cosmetics, pharmaceuticals, and industrial products.
Top Biotech Startups 2026: An Analysis of Emerging Trends
This analysis identifies 20 emerging biotech startups poised to make major impacts by 2026, including companies tackling critical health issues such as Hera Biotech for endometriosis diagnosis and RAGE Biotech for chronic lung diseases, advanced platform technologies like Andson Biotech for mass spectrometry and LatchBio for cloud bioinformatics, environmental solutions including Entomal converting food waste via insects and HydRegen pioneering green catalysts, and novel therapeutics such as Tune Therapeutics' gene therapy for hepatitis B and SpliceBio's intein-based gene splice platform.
Computer-Aided Clinical Trials for Medical Devices: From Research to Reality
The medical device industry is undergoing a significant shift from traditional randomized controlled trials (RCTs) to computational modeling and simulation (CM&S), driven by FDA projections that CM&S will comprise nearly 50% of evidence in submissions by 2025. This article explores how computer-aided clinical trials (CACTs), utilizing digital twins and virtual cohorts, address the challenges of traditional trials by simulating physiological responses across diverse populations and optimizing device algorithms. Case studies from cardiovascular, orthopedic, and diabetes management devices demonstrate successful regulatory approvals and reduced trial enrollments. The article also outlines an implementation framework, discusses current challenges like data quality and regulatory acceptance, and highlights emerging capabilities such as AI-driven optimization and quantum computing, projecting substantial market growth and innovation throughput.
Brainwaves of Mothers and Children Synchronize During Play, Even in an Acquired Language
A UK research team reported in "Frontiers in Cognition" that brain activity (neural synchrony) between bilingual mothers and their 3-4 year-old children synchronizes equally during play, whether they communicate in the mother's native language or an acquired second language (English). This neural synchrony, crucial for parent-child bonding and communication, was particularly strong in the prefrontal cortex during interactive play. The findings suggest that using a second language does not hinder the brain-to-brain connection between parents and children, emphasizing that bilingualism can support healthy communication and learning.
Visualization of Infant Suckling with a Newly Developed Sensor Device
Sumitomo Bakelite Co., Ltd. has developed a suckling sensing device and system that measures infant tongue movements to quantify suckling strength. Collaborative research with Setsunan University demonstrated that this sensor objectively captures tongue movements during suckling, improving the quality of breastfeeding guidance. Utilizing their proprietary "DuraQ® conductive paste," the device achieves flexibility and stable data acquisition. PC software and a smartphone app are also under development. Aiming for a 2027 market launch, future plans include predicting breast milk intake and applying the technology to dysphagia and dysarthria in the elderly.
Human Life CORD and Rohto Pharmaceutical Collaborate on Investigational Product Manufacturing for Phase III Clinical Trials
Human Life CORD Inc. (HLC) and Rohto Pharmaceutical Co., Ltd. announced a collaboration to strengthen the manufacturing and stable supply system for the investigational product to be used in Phase III clinical trials of HLC's umbilical cord-derived mesenchymal stromal cells, "HLC-001." This clinical trial aims to evaluate the efficacy and safety of "HLC-001" in patients with steroid-resistant idiopathic pneumonia syndrome (IPS), a non-infectious pulmonary complication following hematopoietic stem cell transplantation. Rohto Pharmaceutical has entered into a CDMO agreement with HLC to handle cell processing and formulation using seed cells. Both companies are committed to strengthening their collaboration to provide new value in this disease area with limited treatment options and deliver effective treatment options to patients as soon as possible.
Hydrogen-rich jelly confirmed to stabilize autonomic nervous system balance — Significant impact on heart rate variability (HRV) confirmed in collaborative research with Keio University School of Medicine —
Shinryo Corporation, in collaboration with Keio University School of Medicine, confirmed the potential of consuming hydrogen-rich jelly (approx. 30-40ppm hydrogen concentration) to stabilize autonomic nervous system balance. A double-blind, randomized, crossover trial involving 50 healthy adults showed a significant decrease in Heart Rate Variability (HRV) coefficient (CVRR) during orthostatic loading, and a significant decrease in LF and LF/HF ratio (indicating sympathetic and parasympathetic balance) when returning to a seated position. These findings suggest that the jelly suppresses excessive sympathetic nervous system response and promotes parasympathetic dominance. This study is the first to suggest that hydrogen-rich jelly directly influences autonomic nervous system activity during physical exertion, opening avenues for broader health promotion applications such as stress reduction, improved sleep quality, and fatigue recovery support. The research findings have been published as a preprint on "medRxiv," with follow-up studies planned for long-term intake and clinical applications.
Generative AI tool helps 3D print personal items that sustain daily use
MIT CSAIL researchers, in collaboration with Google and others, have developed "MechStyle," a generative AI tool that enables the creation of durable, personalized 3D-printed items. Unlike previous AI systems that often compromised mechanical integrity, MechStyle integrates physics simulations (finite element analysis) to ensure that aesthetic modifications to 3D models do not weaken their structure. Users can input a 3D model and text or image prompts to stylize it, with the system dynamically analyzing and preserving structural viability. This innovation allows for the creation of unique personal accessories, assistive technologies like splints and utensil grips, and home decor, bridging the gap between AI creativity and real-world functional applications, and aiming to make 3D design more accessible to both experts and novices.