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GLUCOSE BIOSENSOR USING PRUSSIAN BLUE FILAMENT
Researchers from the University of Brighton have developed a 3D printed glucose biosensor that can monitor glucose consumption in HepG2 cells. Led by Chloe Miller, alongside Bhavik Anil Patel, Professor of Clinical and Bioanalytical Chemistry, this study employed a method in which Prussian Blue was embedded directly into carbon black/polylactic acid (CB/PLA) filaments before 3D printing. Leveraging FlashForge Creator Pro 3D printer, the method offers a potential workaround to common issues with chemically modified electrodes, especially when it comes to stability and reproducibility. Electrochemical sensors depend heavily on the surface of electrodes, where reactions take place. That’s why surface modifications, such as improving conductivity or enhancing selectivity are often essential. Typically, this involves depositing materials like nanoparticles or enzymes after the electrodes are printed. But those post-printing steps are often complex, time-consuming, and prone to long-term degradation. Published in ACS Publications, the Brighton team instead set out to integrate the active material at an earlier stage.
Innovations in noninvasive sensory stimulation treatments to combat Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. There is no known cure for AD, highlighting an urgent need for new, innovative treatments. Recent studies have shed light on a promising, noninvasive approach using sensory stimulation as a potential therapy for AD. Exposing patients to light and sound pulses at a frequency of 40 hertz induces brain rhythms in the gamma frequency range that are important for healthy brain activity. Using this treatment in animal models, we are now beginning to understand the molecular, cellular, and circuit-level changes that underlie improvements in disease pathology, cognition, and behavior. A mechanistic understanding of the basic biology that underlies the 40-hertz treatment will inform ongoing clinical trials that offer a promising avenue of treatment without the side effects and high costs typically associated with pharmacological interventions. Concurrent advancements in neurotechnology that can also noninvasively stimulate healthy brain rhythms are illuminating new possibilities for alternative therapies. Altogether, these noninvasive approaches could herald a new era in treating AD, making them a beacon of hope for patients, families, and caregivers facing the challenges of this debilitating condition.
MycoTechnology’s honey truffle sweetener receives GRAS approval
Fermented mushroom ingredients maker MycoTechnology received safety approval for a natural flavor enhancer made from honey truffle, which can boost sweet flavors such as caramel while masking unpleasant tastes. MycoTechnology’s ClearHT gained Generally Recognized As Safe (GRAS) status from the Flavor and Extract Manufacturers Association, an industry assessment program.The product will be on the market in early 2026 in countries that accept GRAS determinations. While the U.S. accepts GRAS certifications, Health and Human Services Secretary Robert F. Kennedy Jr. has looked to crack down on self-affirmed food safety assessments.
Harnessing Odorant Receptor Activation to Suppress Real Malodor
Mammals, including humans, sense smell by the responses of odorant receptors (ORs) to odor molecules. We have developed an effective method to identify novel antagonists capable of suppressing the pungent odor of cat urine by targeting specific ORs. Since odors are typically complex mixtures of multiple volatile compounds, olfactory perception can vary depending on the composition. We analyzed the response of ORs to cat urine odor using vapor stimulation assays to identify the responding ORs. Gas chromatography–mass spectrometry was then performed to identify compounds eliciting responses from these ORs. Trace-amine-associated receptor 5 (TAAR5) demonstrated a significant response associated with the odor intensity of cat urine, identifying trimethylamine as a major contributor to the strong odor. From hundreds of candidate compounds, we identified several novel antagonists that exhibited greater efficacy than a known TAAR5 antagonist. These compounds not only reduced the responses of TAAR5-expressing cells to cat urine odor but also significantly reduced odor intensity and improved sensory pleasantness in human tests. Our findings suggest that targeting ORs responsive to specific odors, without isolating their individual components, is a promising strategy for developing deodorizing agents against complex malodors like cat urine odor. This study emphasizes the value of using real odor mixtures to enhance our understanding of odor perception.
Sensory interactive fibers and textiles
Electronic textiles (e-textiles) have gradually emerged as a burgeoning industry, with the advancement of flexible electronic technology and the growing demand for personalization, convenience, and comfort. As the typical representative, sensory interactive e-textiles, integrated with visual, auditory, tactile, and other sensory experiences, have garnered significant attention in the next generation of wearable devices due to their outstanding performance and unique immersive interactive experience. To promote the practical application and better development of sensory interactive e-textiles, this paper reviews the research status of sensory interactive fibers and textiles in recent years, providing a detailed overview of functional fibers capable of achieving sensory interactive functions, categorizes system integration technologies for sensory interactive e-textiles, and summarizes the application scenarios of sensory interactive e-textiles. This review further delineates current design paradigms of e-textiles and proposes a novel design paradigm applicable to sensory interactive e-textiles. Finally, we clarify the challenges facing the future development of sensory interactive e-textiles and suggest vital research directions.
Establishing a method for turning tactile and muscle sensations on and off using light - with hopes for therapeutic applications such as the treatment of spasticity after a stroke
A joint research group consisting of Ryoji Kosugi, a special-appointment laboratory head at the Department of Model Animal Development and Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Moe Kudo, a technical fellow, and Kazuhiko Seki, a department head, as well as Kenichi Inoue, an assistant professor, and Masahiko Takada, a professor, at the Department of Integrative Brain Systems, Research Center for Human Behavioral Evolution, Kyoto University, has established a method for selectively controlling the activity of peripheral sensory nerves involved in tactile and muscle sensation, using optogenetics1). have established a method for selectively controlling the activity of peripheral sensory nerves involved in tactile and muscle sensation. The results of this research are expected to lead to the development of new treatments for numbness and abnormal muscle tension caused by neurological disorders and sensory disorders. Our bodies perceive tactile and pain sensations through sensory nerves that convey information from the external environment to the brain. However, when the function of these sensory nerves is impaired due to stroke or neurodegenerative diseases, symptoms such as pain, numbness and abnormal muscle tension may appear. Conventional drug therapy and electrical stimulation therapy have been problematic in that it is difficult to selectively control specific nerve activity and there is a risk of side effects. The research group therefore focused on optogenetics and developed a new method to selectively control the activity of peripheral sensory nerves, particularly those involved in touch and muscle sensation, using the “power of light”. Specifically, by combining a technique for introducing genes into nerve cells using a virus, a technique for controlling nerve cell activity using light, and a technique for recording nerve cell activity, the research group demonstrated that it was possible to activate or inhibit large-diameter sensory nerve fibers involved in the transmission of tactile and muscle sensations with a high degree of precision. As a result, they succeeded in establishing a method for controlling specific sensory nerve activity at the peripheral nerve level. Using this method, it has become possible for the first time in the world to suppress tactile and muscle sensations before they are transmitted to the brain. The results of this research have made it possible to precisely adjust neural activity, which was difficult with conventional methods, and it is hoped that this will expand the options for more effective treatment of neurological disorders. In particular, it could lead to the development of new treatments for diseases caused by abnormalities in peripheral nerve circuits, such as spasticity after a stroke. The results of this research were published in the online edition of iScience on Thursday, March 27, 2025 at 1:00 am (Japan time).
Waterproof and conductive tough fibers for washable e-textile
Conductive fibers are essential for wearable electronics, especially in electronic textiles (e-textiles) used as skin-interfaced sensors and interconnects. Achieving sustainable e-textiles with integrated toughness, waterproofing, and washability remains challenging. We present waterproof conductive tough fibers (CTFs) fabricated via a scalable, continuous capillary tube-assisted coating (CTAC) process. The multilayered CTFs demonstrate a conductivity of 6.42 kS/cm, Young’s modulus of 6.22 MPa, toughness of 9.40 × 105 J/m3, and 70% strain at break. With lengths exceeding 20 m, a native oxide layer on the eutectic gallium-indium (EGaIn) shell ensures reliable waterproofing with the IPX8 standard. They also maintain consistent performance for 24 days water immersion and repeated washing up to 100 cycles, showing superior resistance retention compared to the EGaIn-absence fibers. As a proof-of-concept, they enable wireless power transfer and reliable monitoring of electrocardiogram and electromyogram signals, establishing a robust platform for sustainable e-textiles.
IFF Introduces Science of Performance: A New Approach to Elevating Scent Design
IFF (NYSE: IFF) unveils its Science of Performance program, a comprehensive, science-driven suite that enhances fragrance creation by increasing efficiency and precision to manage scent intensity and control malodors. The program combines decades of measured data enhanced by proprietary AI capabilities, along with advanced sensory, technical, consumer and market expertise in various end-user applications. "Science of Performance is a unique approach to scent performance design that leverages key scientific enablers to deliver highly customized and high-performing solutions globally," said Valery Claude, senior vice president of innovation, IFF Scent. "Our evolving technologies are empowering our perfumers and partners to more effectively meet diverse customer demands and expectations in fragrance, personal care, and home care."
Training AI technology with 10,000 diverse hair images. Recommending personalized hair care products from a robust data set.
Perfect Corp. (PERF) has launched its new AI Frizzy Hair Analyzer, expanding its AI Hair Analysis suite. The tool analyzes hair frizz levels in seconds using three photos (front, left, right views) and categorizes frizz into four levels: smooth, slightly frizzy, moderately frizzy, and extremely frizzy.
Characterising the inconsistency between perceived and actual sleep and its impact upon cognition and mood
Sleep profoundly influences human behaviour across cognition, affect, and daily experience. This study evaluated how subjective reports and objective measures of sleep capture the interaction between sleep quality and quantity on cognition and affect. We collected subjective sleep reports using the Pittsburgh Sleep Quality Index and objective seven-day actigraphy recordings from 83 participants. A test battery, including the Stop Signal, Digit Span, and Emotional Bias Tasks, measured response inhibition, working memory, and affect. Mood was evaluated using the Positive and Negative Affect Schedule, State-Trait Anxiety Inventory, and Beck’s Anxiety Inventory. We reveal that subjective sleep reports do not predict objectively measured sleep duration or quality. We demonstrate that objective measures predict cognitive performance on executive function and memory tasks for the upper and lower sleep quartiles, while subjective reports do not. Moreover, we demonstrate that subjective reports, but not objective measures, are strongly predicted by emotional state. These findings suggest that while subjective measures do not accurately index actual sleep, they are a reliable proxy for emotional well-being. We propose that combined subjective and objective measures are required to characterise the multifaceted interaction between sleep, cognition and emotion. We discuss the implications of these findings for understanding the cause-effect relationship of sleep-disturbance in neurological and psychiatric disorders.
Elucidation of The Effect of Flossing on Improving Joint Range of Motion
Flossing is one of the conditioning methods used in sports. One of the purposes of its use was thought to be to improve and increase the range of motion of joints by improving the gliding properties of the fascia, but it was not clear whether it affected the fascia or whether the range of motion of the joints actually changed. The results of this study confirmed a decrease in the hardness of the fascia in the upper part of the gastrocnemius muscle and an increase in the range of motion of the dorsiflexion of the ankle joint. This revealed the possibility that improving the gliding properties between fascia contributes to improving and increasing the range of motion of joints.
Non-invasive FDA-approved sleep solution for the treatment of chronic insomnia
Neurovalens, a global health-tech leader in neurotechnology, has been awarded the prestigious National Sleep Foundation's (NSF) 2024 SleepTech® Award in the Sleep Disorders and Conditions category for its product, Modius Sleep.
Identifying a blood biomarker that predicts the prognosis of heavy ion radiotherapy for pancreatic cancer
While heavy ion therapy for pancreatic cancer is sometimes ineffective, it has not been possible to predict prognosis as information that is useful for treatment selection. It has been found that the higher the concentration of biomarkers in the blood before heavy ion therapy, the less likely it is that distant metastasis will occur after treatment. It is hoped that this will become useful information for selecting heavy ion therapy in the future.