DxMedical Cloud™
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Explore the future of healthcare with carefully selected information.
Explore the future of healthcare with carefully selected information.
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We deliver what you seek quickly and in a short time from technical information from all over the world
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In today's world, where the world is networked by advances in information technology and numerous technologies are evolving at an astonishing speed, it is extremely difficult to manually collect and manage the vast amount of information from all over the world.
DxMedical Cloud™ collects and analyzes professional information from around the world and uses proprietary algorithms to quickly and accurately deliver the information you seek and the best information for you.
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You can quickly search for information published in various languages around the world in Japanese. Get the information you need from the vast amount of information available worldwide without having to worry about language barriers.
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DxMedical Cloud's proprietary algorithms predict the best information based on your interests and preferences and deliver it to you daily. Stay one step ahead of the curve without the hassle of searching, maximizing your daily information gathering.
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In addition to word matching, the search by similar and related keywords delivers news that is often missed due to paraphrasing and shaky spelling.
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By providing titles and summaries of information from around the world in Japanese, it streamlines the process of “finding” the information you want from search results.
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For researchers and professionals, you can search and browse more specialized information, such as articles submitted to journals by universities and research institutes.
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Instantly save and manage information that you like or want to look at later because you don't have time, with the bookmark function. You can access the information you need without hassle, saving you a great deal of time and effort.
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Simple and intuitive operation allows you to quickly consolidate all information into a notebook and organize information efficiently. It can be used as a powerful tool for effective information sharing.
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A wide range of information sharing tools are available, including chat and note sharing functions. We support information sharing with your team in all situations, from casual information sharing to organizing information in teams.
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Provides task management functions specifically designed to make information gathering and sharing more efficient. In addition to regular task management functions, this useful tool supports information gathering and sharing, improving the productivity of the entire team.
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Technology
Targeted Antimicrobial Peptide Toothpaste Kills Gum Disease Bacteria While Protecting Healthy Oral Flora New Approach Overcomes Broad-Spectrum Bactericidal Effects of Conventional Toothpaste
SciTechDaily (2026) reported on the development of a toothpaste that selectively kills periodontal disease-causing bacteria while leaving the healthy oral microbiome (resident flora) unharmed. Conventional toothpastes and antimicrobial mouthwashes often use broad-spectrum bactericidal agents such as chlorhexidine, which eliminate not only periodontal pathogens but also beneficial resident bacteria—a longstanding dilemma in oral care. The new approach utilizes antimicrobial peptides that selectively bind to and kill major periodontal pathogens (anaerobic oral bacteria such as Porphyromonas gingivalis). Because the peptides target specific components of the bacterial membrane found in these pathogens, they are designed not to act against structurally different beneficial resident bacteria. Periodontal disease affects approximately half of Japanese adults and is a risk factor for cardiovascular disease, diabetes, and dementia. The approach offers potential as a daily care supplement to conventional treatments (scaling, root planing, antibiotics) and is attracting attention from the perspective of protecting the oral microbiome.
Engineered Enzyme Breakthrough: 2-Fold Improvement in Polyurethane Recycling Efficiency Through Structural Analysis and Protein Engineering of Esterase Aes72
EurekAlert! (April 1, 2026; published in Engineering) reported that a research team from Nanjing Tech University, Shandong University, the Tianjin Institute of Industrial Biotechnology, and the University of Greifswald elucidated, for the first time, the catalytic mechanism by which esterase Aes72 hydrolyzes urethane bonds in polyurethane (PU), and engineered the enzyme to achieve 2-fold improvement in catalytic efficiency over the wild-type. Polyurethane is the fifth most-produced synthetic polymer globally and its waste management is a worldwide challenge. Current mechanical or chemical recycling methods suffer from high energy consumption, unwanted byproducts, and strict raw material quality requirements. The team resolved the crystal structure of Aes72 at 1.80 Å resolution and used QM/MM simulations to map the four-step catalytic mechanism, identifying nucleophilic attack as the rate-determining step. Using a semi-rational design strategy to engineer the binding pocket, the double mutant F276A/L141I achieved 2-fold improvement in catalytic efficacy toward model substrate BMC and significantly enhanced degradation of polyether-based PU waste. As a biocatalytic technology operating under mild conditions without organic solvents, it is expected to contribute to environmentally sustainable plastic recycling for a circular economy.
Sleep Data from Wearable Device May Help Predict Preterm Birth
MSN Health (published in npj Women's Health, from Washington University in St. Louis) reported a study showing that variability in sleep patterns collected from wearable devices during pregnancy can effectively predict preterm birth (delivery before 37 weeks). Study overview: Graduate student Ben Warner and Associate Professor of Obstetrics & Gynecology Peinan Zhao used machine learning models to analyze sleep data from 665 pregnant patients (first and second trimesters). Patients wore an actigraph (clinically validated wrist-based motion sensor) for approximately two-week periods. About 14% of the cohort experienced preterm birth. Key findings: Variability in sleep patterns (lack of consistency in sleep schedules) is a stronger predictor of preterm birth than average sleep metrics (duration/quality). That is, maintaining regular sleep rhythm is more important than getting good sleep on average. Early signal detection before 20 weeks of pregnancy is possible. According to WHO, 75% of preterm birth-related deaths in children under 5 could be prevented with interventions, but lack of prediction methods has been a barrier. Clinical significance: Currently no effective method exists to identify high-risk pregnancies in advance. This study provides a new approach to predicting which pregnant individuals are at higher risk before birth. Future research will validate results in other populations and academic medical centers.
Study Finds Kale Consumption Affects Blood Pressure and Vascular Function; Research Examines Link to Antioxidant Properties
Research conducted by Kyusai has shown that regular consumption of kale may influence biological markers related to blood pressure and vascular function. The company had previously confirmed the blood pressure-lowering effects of kale consumption; in this latest study, it focused on two additional markers—“potential antioxidant capacity” and “vascular flexibility”—to verify their physiological effects. The research was motivated by the fact that hypertension is a major health issue in Japan. Hypertension is considered one of the leading causes of stroke and heart disease, and preventive approaches in the pre-symptomatic stage are highly prioritized. The company focused on “potential antioxidant capacity,” an indicator of the body’s oxidative stress status, and “vascular flexibility,” which evaluates the condition of blood vessels. Vascular flexibility is assessed by factors such as the speed of the pulse wave traveling through the vessels and is known to decline with increased oxidative stress. In the study, continuous intake of kale powder was confirmed to improve both potential antioxidant capacity and vascular flexibility. The findings suggest that the improvement in antioxidant capacity leads to the alleviation of oxidative stress, which in turn may contribute to reducing the risk of decreased vascular flexibility. While kale is known to be rich in antioxidant-related components such as polyphenols, a single specific component responsible for these effects has not yet been identified. The company believes that the interactions among the diverse nutrients in kale may be involved and plans to consider conducting verification at the component level in the future. As a company that has been consistently engaged in everything from kale cultivation to product development, the company has promoted the health benefits of kale through products such as green juice. Moving forward, under the banner of “well-aging,” the company intends to strengthen its approach to the pre-disease stage—the “pre-disease” domain—and advance product development that leads to behavioral changes among consumers.
Swiss Biotech Startup Wins First Prize in Food as Medicine Accelerator, Developing AI-Driven Upcycled Plant Bioactives to Reprogram Gut Microbiome for Brain and Immune Health
Swiss Food & Nutrition Valley (October 2025) reported that Trilliome, a Lausanne-based biotech startup, won first prize in the EIT Food Accelerator Network's 'Food as Medicine' programme, receiving €50,000 in Tech Validation Funding. The company is developing precision bioactives that reprogram the gut microbiome to restore brain and immune health for healthy aging. Its proprietary AI-driven discovery platform and human gut model identify molecular combinations that transform upcycled fruit and plant waste streams into targeted gut bioactives. Early studies in human models show increased levels of beneficial gut bacteria and higher production of short-chain fatty acids such as butyrate and propionate, compounds linked to cognitive health, mood regulation, and immune balance. In addition to the EIT Food prize, Trilliome also earned second prize at the Aging Research and Drug Discovery (ARDD) Conference and the Probiota Americas Pioneer Prize in 2025. The Tech Validation Award funding will be used to advance clinical validation, scalable manufacturing, and regulatory readiness, enabling new partnerships across the ingredients, supplements, and medical foods sectors.
【PRESS RELEASE】CellFiber Unveils New GMP-Compliant Cell Fiber Fabrication System”CellFiber Extruder” for Regenerative Medicine ～Enabling Efficient and Stable Manufacturing of Cell Therapy Products～
CellFiber Inc. has unveiled its production-scaled, GMP-compliant “CellFiber Extruder,” a cell fiber fabrication system designed to enable efficient and stable large-scale manufacturing of cell therapy products for regenerative medicine. This innovative encapsulation technology, CellFiber®, protects cells in a biomimetic alginate structure, improving functional maintenance and viability. The Extruder system automates production, offers flexibility for various cell cultures, operates as a closed system to minimize contamination, and provides traceability for regulatory compliance, addressing critical bottlenecks in cost-efficient, industrial-scale cell manufacturing globally.
Portal Diabetes Receives FDA Breakthrough Designation for Pump, Initiates Insulin Study
Portal Diabetes, Inc. announced that its implantable insulin pump system, "Portal Pump," has received Breakthrough Device Designation from the U.S. Food and Drug Administration (FDA), and a Phase 1 study has commenced for its proprietary temperature-stable insulin, "Portal Insulin." The company aims to provide a functional cure for type 1 diabetes by creating a fully closed-loop insulin delivery system, integrating physiological insulin delivery to the abdomen, modern continuous glucose monitoring (CGM) technology, and stable, concentrated insulin. The Breakthrough Device Designation will facilitate priority interactions with the FDA for clinical trials and regulatory approvals, and qualifies the system for expedited Medicare coverage through the TCET pathway. The recent first clinical injections of Portal Insulin mark a significant milestone, with clinical trials for the combined system expected to begin around Q4 2027.
iotaMotion Receives FDA Clearance for Pediatric Use of iotaSOFT®, its Robotic-Assisted Cochlear Implant Insertion System
iotaMotion, Inc., developer of the FDA-approved iotaSOFT® robotic-assisted cochlear implant insertion system, has announced FDA 510(k) clearance for its pediatric use (ages four and up), expanding access to robotic-assisted cochlear implantation for school-aged children. The iotaSOFT system ensures precise and controlled electrode insertion during one of the most delicate steps of cochlear implant surgery, standardizing the procedure and potentially reducing variability, thereby offering greater confidence to parents considering implants for their children. Cincinnati Children's Hospital is the first pediatric center to adopt this system. Clinical studies indicate improved hearing preservation rates with robotic-assisted insertion compared to manual methods, a critical factor for early sound perception development in pediatric patients and for the success of future advanced therapeutic technologies.
Career Survival and Shinnichi Kogyo Launch Joint Project for AI-Powered "3D Shape Inspection and Anomaly Analysis System"
AI startup Career Survival and manufacturer Shinnichi Kogyo have launched a joint development and demonstration project for an "AI-powered 3D shape inspection and anomaly analysis system." Addressing the aging of skilled workers and labor shortages in manufacturing, this system uses AI to analyze 3D scan data of products, enabling high-precision inspection and anomaly cause analysis without expensive sensors. The aim is to achieve stable quality and technology transfer at low cost, accelerating DX in the manufacturing industry.
Synthetic key enzyme enables the conversion of CO₂ into formic acid
For a carbon-neutral bioeconomy, processes are needed that can efficiently capture CO2 and convert it into valuable products. Formic acid, or more specifically its salt, formate, is considered a promising candidate as it can be produced from CO₂ using renewable electricity. It is also easy to transport, non-toxic and versatile. Research is focusing, among other things, on microorganisms that are "fed" formic acid made from CO₂ and use it to produce basic chemicals or fuels.
Elucidating abnormalities in gut microbiota and sex differences in Japanese adult bronchial asthma patients
Symbiosis Solutions, in a joint research with the Department of Respiratory Medicine at Nihon University School of Medicine, discovered abnormalities (dysbiosis) in the gut microbiota of Japanese adult bronchial asthma patients, with sex differences observed in the types of associated bacteria. While previous studies have reported a link between childhood asthma and gut microbiota, this connection in adult asthma was previously unclear. This study revealed an abnormal gut microbiota composition in adult asthma patients, characterized by a higher abundance of respiratory disease-related bacterial groups and fewer short-chain fatty acid-producing bacteria, also demonstrating sex-specific differences in these abnormalities. These findings suggest that gut microbiota could be a new target for the prevention and improvement of adult bronchial asthma, emphasizing the importance of considering sex differences in future approaches. The research was published in the international academic journal 'Biomedicines'.
From 3D to AI and Beyond, How Hologic Continues to Shape the Future of Mammography
Hologic was the first to receive FDA approval for a 3D™ mammography (digital breast tomosynthesis) system in 2011. As the company celebrates 40 years of innovation, our team continues to lead the way in breast cancer detection with AI, advanced imaging, and novel technologies that keep the patient front and center.
Lightera Advances Fiber-integrated Temperature Feedback for Safer Laser-based Medical Procedures
Lightera, a global leader in advanced specialty optical fiber solutions, has announced a new development program that integrates real-time fiber-optic temperature sensing with precision laser power delivery into a single fiber platform for safer laser-based medical procedures. This system, designed for medical applications requiring critical thermal accuracy, provides point-of-energy temperature feedback at the treatment site, enabling more consistent control during laser-assisted procedures. This approach is particularly important for intravascular interventions, where unintended heat can increase the risk of clot formation or vessel injury. The dual-function capability reduces system complexity and supports new device designs for thrombosis management, vessel remodeling, and laser atherectomies.